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Solvent‐Free Single‐Pot Mannich Reaction and Detoxification of Industrial Hazardous Waste Methyl Mercaptan Gas
Author(s) -
Swain Sharada Prasanna,
Prasad Nagendra,
Reddy Latchi,
Subrahmanyam G.,
Mohanty Sandeep
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202004447
Subject(s) - hazardous waste , petrochemical , waste management , chemistry , green chemistry , detoxification (alternative medicine) , organic chemistry , catalysis , reaction mechanism , engineering , medicine , alternative medicine , pathology
Environment pollution is causing serious human health issues and forest deterioration. Methyl mercaptan is a malodorous gaseous pollutant, which is a by product of sewage treatment plants, pulp plants, petrochemical plants, agrochemicals, and some pharmaceutical products. A long term exposure to methyl mercaptan may lead to adverse effects on central nervous system and cardiovascular system. The pharmaceutical industries are devoting significant efforts to develop process by using green solvents like water, and develop solvent‐free reactions. This will help to develop green, sustainable methods for the synthesis of API and reduce the manufacturing cost. A ZnCl 2 catalyzed solvent‐free, one‐pot process for the synthesis of ranitidine and quenching of hazardous waste methyl mercaptan gas to a useful product have been developed.