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Synthesis and Anticancer Evaluation of Benzimidazole Derivatives Having Norbornene/Dibenzobarrelene Skeletons and Different Functional Groups
Author(s) -
Çapan İrfan,
Servi Süleyman,
Dalkılıç Semih,
Dalkılıç Lütfiye Kadıoğlu
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202004034
Subject(s) - benzimidazole , chemistry , imide , maleic anhydride , cycloaddition , organic chemistry , copolymer , catalysis , polymer
Two different anhydrides having norbornene and dibenzobarrelene skeletons were synthesized from Diels‐Alder cycloaddition reactions using dienes such as anthracene and cyclopentadiene, and dienophiles like maleic acid and maleic anhydride. New benzimidazole derivatives bearing carboxamide, guanidine, and cyclic imide functional groups were obtained from these anhydrides. The compounds were investigated for their effects on MDA‐MB‐231 (Human breast cancer), A549 (Lung cancer), Ovcar3 (Human Ovarian cancer), and Panc1 (human pancreas cancer) cell lines using the MTT assay test. Compounds 4 – 8 demonstrated critical cytotoxic action against all cell lines.