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Rh(III)‐Catalyzed C2‐Alkylation of Indoles with Maleimides at Low Catalyst Loadings
Author(s) -
Liu ShuangLiang,
Liang Huihui,
Yang Haoran,
Gao Lijun,
Zhou Liming,
Fang Shaoming,
Song MaoPing
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202004021
Subject(s) - catalysis , alkylation , chemistry , pyridine , functional group , organic chemistry , reaction conditions , combinatorial chemistry , polymer
The Rh(III)‐catalyzed C2‐alkylation of indoles with maleimides is disclosed under additive‐free conditions by employing pyridine as a removable directing group. This protocol features low catalyst loadings, simple reaction conditions and good functional group tolerance. In addition to various indoles and maleimides, arenes, pyrroles, maleates as well as ethyl acrylates are applicable substrates.