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Sulfuration‐Triggered Radical Cyclization of o ‐Cyanoarylacrylamides to 3‐Thiomethylated Quinoline‐2,4‐dione
Author(s) -
Yin Zizhen,
Yu Yingjie,
Li Chunxiang,
Mei Haibo,
Zhu Kai,
Han Jianlin
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003999
Subject(s) - quinoline , chemistry , radical cyclization , scope (computer science) , substrate (aquarium) , radical , combinatorial chemistry , cascade , hydrogen peroxide , organic chemistry , peroxide , free radical reaction , computer science , chromatography , oceanography , programming language , geology
A radical cascade sulfuration/cyclization of o ‐cyanoarylacrylamides with dicumyl peroxide as an oxidant and thiols as coupling partners has been developed. This reaction was conducted under simple conditions and showed wide substrate scope, affording the corresponding products in good chemical yields. This work provides a new and efficient strategy for the preparation of 3‐thiomethylated quinoline‐2,4‐diones.