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I 2 ‐Catalyzed Intermolecular Cyclization to Synthesis of 3‐Acylated Indolizines
Author(s) -
Zheng Jing,
Chen Linli,
Liu Xiaojuan,
Xu Wenju,
Wang Yan,
He Qin,
Liu Hanqing,
Ye Min,
Luo Guotian,
Chen Zhengwang
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003849
Subject(s) - indolizine , intermolecular force , catalysis , chemistry , nitrogen , conjugated system , organic chemistry , combinatorial chemistry , molecule , polymer
Indolizine is one of the important nitrogen containing heterocycles due to their wide range of bioactivities. A convenient and efficient intermolecular cyclization reaction catalyzed by I 2 was developed, affording 3‐acylated indolizines in good to excellent yields. 2‐Pyridylacetonitrile, 2‐pyridylacetone and 2‐pyridylacetamides were all compatible, and water was considered as the source of the carbonyl oxygen in the products. Furthermore, the conjugated enynenitriles were afforded from 2‐pyridylacetonitrile with ynals in high yields.