Organocatalytic Enantioselective Cycloaddition of  o ‐Quinone Methides with Oxazolones: Asymmetric Synthesis of Dihydrocoumarins | Zendy

Kim Kyeong Seop | Zendy; Jang Jihoon | Zendy; Kim Dae Young | Zendy

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Organocatalytic Enantioselective Cycloaddition of o ‐Quinone Methides with Oxazolones: Asymmetric Synthesis of Dihydrocoumarins

Author(s) -

Kim Kyeong Seop,

Jang Jihoon,

Kim Dae Young

Publication year - 2020

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.202003817

Subject(s) - enantioselective synthesis , bifunctional , squaramide , cycloaddition , quinone , chemistry , organocatalysis , organic chemistry , catalysis , combinatorial chemistry

The organocatalytic enantioselective cycloaddition of ortho ‐quinone methides with oxazolones promoted by a chiral binaphthyl‐modified squaramide bifunctional organocatalyst was developed, allowing an efficient synthesis of chiral dihydrocoumarins with excellent enantioselectivity (up to 97 % ee). This approach represents a practical method for the preparation of chiral 3,4‐dihydrocoumarin derivatives.

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