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Efficient Synthesis and Computational Studies of Useful Guanylating Agents: 1 H ‐Benzotriazole‐1‐carboximidamides
Author(s) -
Bokhtia Riham M.,
Panda Siva S.,
Girgis Adel S.,
Pillai Girinath G.,
Ibrahim Tarek S.,
Shalaby ElSayed M.,
Gigli Lara,
AbdelAal Eatedal H.,
AlMahmoudy Amany M. M.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003796
Subject(s) - benzotriazole , aryl , recrystallization (geology) , combinatorial chemistry , chemistry , solvent , computational chemistry , organic chemistry , alkyl , biology , paleontology
A new synthetic protocol for the synthesis of 1 H ‐benzotriazole‐1‐carboximidamides starting from aryl amines in presence of acylbenzotriazole has been reported. The versatile guanylating agents could be an efficient synthetic tool for the synthesis of various guanidines. The present approach enables all possible variations of the substituents at different positions of the products. Single crystal of compound 4e was obtained by recrystallization from suitable solvent systems for X‐ray and DFT studies. The reaction goes faster and yields more product with higher purity when Cbz protected aminoacyl benzotriazole used instead of aryl benzotriazole for the synthesis of the 1 H ‐benzotriazole‐1‐carboximidamides. Computational studies were carried out to elucidate the energy profile and transition states to support the experimental data. Short reaction time, simple workup, high yields, and mild conditions are the key advantages of this protocol.