Premium
A Practical Synthesis of 1‐Azine‐pyridin‐2(1H)‐ones from Azine N ‐oxides and Pyridin‐2(1H)‐ones under Mild Reaction Conditions
Author(s) -
Bi WenZhu,
Zhang WenJie,
Li ZiJie,
Feng SuXiang,
Chen XiaoLan,
Qu LingBo
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003792
Subject(s) - azine , chemistry , phosphonate , coupling reaction , combinatorial chemistry , reaction conditions , organic chemistry , medicinal chemistry , catalysis
Through direct coupling reaction of azine N ‐oxides with readily available pyridin‐2(1H)‐ones, a facial and practical strategy was developed for the synthesis of 1‐azine‐pyridin‐2(1H)‐one derivatives in the presence of diethyl H ‐phosphonate, CCl 4 and Et 3 N at room temperature for 0.5 h. This reaction features metal‐free and mild reaction conditions, short reaction time, ease of scale up and wide scope of products.