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Iron‐Promoted Synthesis of (2‐Oxy/Thio)benzothiazole
Author(s) -
Parvathi Edalada Venkata Krishna,
Pinapati Srinivasa rao,
Tamminana Ramana,
Rudraraju Ramesh raju
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003747
Subject(s) - benzothiazole , thio , substituent , yield (engineering) , chemistry , catalysis , coupling reaction , reaction conditions , combinatorial chemistry , medicinal chemistry , organic chemistry , materials science , metallurgy
The synthesis of (2‐Phenoxy)benzothiazole and (2‐Phenylthio)benzothiazole has been demonstrated in the presence of iron catalyst under mild reaction conditions. Library of target compounds are prepared under optimized reaction conditions. Both electron donating and electron withdrawing substituent's are readily carried out the reaction to provide their respective target products in moderate to good yield. Mechanistic studies have suggested that the methodology involves intra molecular C‐S cross‐coupling approach.
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