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Catalyst Free, Multicomponent Green Approach to Benzo[ a ]chromeno[2,3‐ c ]phenazines Using Glycerol as a Recyclable and Biodegradable Promoting Medium
Author(s) -
Nazeef Mohd,
Saquib Mohammad,
Tiwari Saurabh Kumar,
Yadav Vikas,
Ansari Saif,
Sagir Hozeyfa,
Hussain Mohd. Kamil,
Siddiqui I. R.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003732
Subject(s) - glycerol , substrate (aquarium) , catalysis , atom economy , green chemistry , chemistry , combinatorial chemistry , phenazine , organic chemistry , reaction conditions , protocol (science) , reaction mechanism , medicine , oceanography , alternative medicine , pathology , geology
A series of benzo[ a ]chromeno[2,3‐ c ]phenazine derivatives were synthesized through an efficient one‐pot, multicomponent eco‐friendly reaction of 2‐hydroxynaphthalene‐1,4‐dione, o ‐phenylenediamines, cyclic 1,3‐dicarbonyl compounds and aromatic aldehydes, promoted by glycerol. To the best of our knowledge this is the first catalyst free protocol for synthesis of this important scaffold having potential applications in medicinal and materials chemistry. Other important attributes of the present method are the use of glycerol as a bio‐renewable and biodegradable reaction medium‐cum‐promoter, use of readily available substrates, mild reaction conditions, operational simplicity, broad substrate scope, short reaction time, easy workup, and high yields and atom efficiency, which makes the disclosed protocol a superior alternative to existing methods.