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A Fluorescent Turn‐on Probe Based on Zn‐doped AgIn 5 S 8 Quantum Dots for Imaging of Hydrogen Sulfide in Living Cells
Author(s) -
Dong Yanyu,
Sun Wenping,
Chang Shiqi,
Li Tong,
Huang Xiaohua,
Xing Shanghua,
Bai Tianyu,
Ma Huipeng
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003729
Subject(s) - fluorescence , chemistry , quantum dot , membrane permeability , copper , biophysics , quenching (fluorescence) , hydrogen sulfide , membrane , photochemistry , nanotechnology , materials science , biochemistry , quantum mechanics , biology , physics , sulfur , organic chemistry
H 2 S has been identified as endogenously generated gasotransmitter in mammalian which acts essential role in various physiological and pathological processes. In this work, we reported the use of hydrophilic, low‐toxic and photostable Zn‐doped AgIn 5 S 8 quantum dots (ZAIS QDs) in H 2 S detection. Copper ions, acting as recognition moieties, are conjugated on the surface of ZAIS QD to construct the fluorescent probe. The weak fluorescence signal of the probe owing to the quenching effect of paramagnetic Cu 2+ center on ZAIS QDs can exhibit significant fluorescence turn‐on property upon the addition of H 2 S. Simultaneously, the probe possesses high sensitivity at physiological pH, excellent membrane permeability and dose‐dependent fluorescence imaging of exogenous H 2 S in living cells.