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Azaphosphatranes Catalyzed Strecker Reaction in the Presence of Water
Author(s) -
Yang Jian,
Manick AnneDoriane,
Li Chunyang,
Bugaut Xavier,
Chatelet Bastien,
Dufaud Véronique,
Hérault Damien,
Martinez Alexandre
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003602
Subject(s) - cyanation , trimethylsilyl cyanide , strecker amino acid synthesis , catalysis , chemistry , cyanide , safer , organic chemistry , computer security , computer science , enantioselective synthesis
Abstract Azaphosphatranes were found to act as efficient organocatalysts in the presence of water for the cyanation of differently substituted imines. A relatively safer source of cyanide, trimethylsilyl cyanide (TMSCN), was used, and excellent yields could be obtained with only 0.05 mol % of catalyst. The influence of acidity of azaphosphatranes on catalytic activity as well as the role of azaphosphatranes in the mechanism of the reaction were also investigated.