Premium
Water Extract of Lemon (WEL) as a Promoter: Green and Regioselective Synthesis of Alkyl‐4‐(1 H ‐indol‐3 yl)‐2‐alkyl‐4 H ‐chromene‐3‐carboxylates Using 4 H ‐chromenes and Indoles
Author(s) -
Lenin Dandamudi V,
Rao L. Chandrashekhara,
Satish Kumar Nandigama
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003542
Subject(s) - regioselectivity , alkyl , catalysis , yield (engineering) , chemistry , organic chemistry , combinatorial chemistry , materials science , metallurgy
Abstract An efficient, simple, green, regioselective and catalyst‐free synthesis of alkyl‐4‐(1 H ‐indol‐3yl)‐2‐alkyl‐4H‐chromene‐3‐carboxylates is disclosed by employing indoles and substituted chromene derivatives under mild reaction condition. This is a novel green methodology, simple, eco‐friendly and easy to operate. Biomass‐derived catalyst Water Extract of Lemon (WEL) was used as a promoter for this procedure. The methodology could be applicable for cost‐effective large scale production of alkyl‐4‐(1 H ‐indol‐3yl)‐2‐alkyl‐4 H ‐chromene‐3‐carboxylates in good to excellent yield.