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Iodination of Isoquinoline by Trifluoromethanesulfonic Acid
Author(s) -
Xu Peng,
He XiaLi,
Zhang YingYang,
Sun XiaoNan,
Bai JiRong,
Zhou Pin,
Zhou QuanFa
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003539
Subject(s) - halogenation , isoquinoline , regioselectivity , chemistry , compatibility (geochemistry) , combinatorial chemistry , organic chemistry , functional group , medicinal chemistry , catalysis , materials science , polymer , composite material
In this paper, we reported an unprecedented iodination of isoquinolines with high regioselectivity using N ‐Iodosuccinimide (NIS) to give 5‐iodoisoquinoline. During the reaction, CF 3 SO 3 H is the key promoter to the success of this reaction. The methodology exhibited good yields and high functional group compatibility.