Premium
Enantiomeric N ‐ tert ‐Butylsulfinyl Imines of Methyl Trifluoropyruvate: Promising Building Blocks in Asymmetric Synthesis of α‐Trifluoromethylated Amino Acids and Derivatives
Author(s) -
Cherednichenko Alona S.,
Bezgubenko Ludmyla V.,
Rusanov Eduard B.,
Onys'ko Petro P.,
Rassukana Yuliya V.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003500
Subject(s) - enantiomer , amino acid , chemistry , nitro , enantiomeric excess , organic chemistry , enantioselective synthesis , combinatorial chemistry , biochemistry , catalysis , alkyl
A convenient synthetic method for ( R )‐ and ( S )‐ N ‐ tert ‐butylsulfinyl imines of methyl trifluoropyruvate has been developed. The synthetic potentialities of these chiral building blocks for the preparation of nonracemic trifluoroalanines, trifluoromethylated amino alcohols, β‐nitro‐α‐amino acids, and pyrrolinone carboxylic acid derivatives have been demonstrated.