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Synthesis and Biological Evaluation of New 4,5,6,7‐Tetrahydro‐1 H ‐imidazo[4,5‐ c ]pyridine Derivatives
Author(s) -
Prezent Mikhail A.,
Baranin Sergey V.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003440
Subject(s) - chemistry , pyridine , abts , aryl , combinatorial chemistry , organic chemistry , medicinal chemistry , antioxidant , alkyl , dpph
A number of new spinaceamine derivatives have been synthesized by the Suzuki reaction of 5‐Boc‐2‐iodo‐spinaciamine with aryl or heteryl boronic acids. The obtained compounds exhibited a varying degree of ABTS radical‐scavenging activity, and some of them found to be more effective radical‐scavengers comparing with spinacine. Both spinacine and its synthesized derivatives do not inhibit cholinesterases and carboxylesterase.