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Base Promoted Cascade Reaction: A Convenient Route to Hybrid S and N Polyheterocycles
Author(s) -
Jayarajan Ramasamy,
Kottha Thirumalaswamy,
Subbaramanian Sabarinathan,
Vasuki Gnanasambandam
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003412
Subject(s) - chemoselectivity , cascade , cascade reaction , combinatorial chemistry , chemistry , methylene , pyrimidine , component (thermodynamics) , stereochemistry , organic chemistry , catalysis , chromatography , physics , thermodynamics
Biologically privileged fused pyrimidine spirocycles were synthesized via a metal‐free three‐component cascade reaction utilizing mercapto/aza lactam active methylene compounds. This rapid and efficient one‐pot operation quickly delivered seven different polycyclic and spirocyclic scaffolds such as pyranothiazolopyrimidine, benzothiazolopyranopyrimidine, pyranotriazolopyrimidine, benzoimidazolopyranopyrimidine, spiroindolinepyranothiazolopyrimidine, spirobenzothiazolopyranopyrimidineindoline, and spirobenzo‐imidazolopyranopyrimidineindoline at room temperature with excellent regio/chemoselectivity.