Studies Towards the Synthesis of Pristinamycin II A | Zendy

Sušnik Peter | Zendy; Koert Ulrich | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Studies Towards the Synthesis of Pristinamycin II A

Author(s) -

Sušnik Peter,

Koert Ulrich

Publication year - 2020

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.202003411

Subject(s) - substructure , natural product , ring (chemistry) , stereochemistry , chemistry , stereoselectivity , combinatorial chemistry , organic chemistry , engineering , structural engineering , catalysis

Studies towards a total synthesis of pristinamycin II A ( 1 ) as part of group A streptogramins is described. Stereoselective syntheses of three building blocks A, B and C including the 2,3‐dehydroproline substructure and their assembly into advanced CAB‐precursor molecules for the natural product was achieved. Attempts to close the macrocylic ring at a late stage by Sm 2 /Barbier or Nozaki‐Hiyama‐Takai‐Kishi‐reaction demonstrate challenges and limitations of this approach.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research