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7‐(β‐ D ‐Ribofuranosyl)guanine and its Analogues Modified in the Sugar Portion: Synthesis and Antiglioma Properties
Author(s) -
Wawrzyniak Dariusz,
Framski Grzegorz,
Januszczyk Piotr,
Ostrowski Tomasz,
Baraniak Dagmara,
JahnzWechmann Zofia,
Fogt Joanna,
Manikowski Andrzej,
Baranowski Daniel,
Rolle Katarzyna,
Boryski Jerzy
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003393
Subject(s) - guanine , hela , cytotoxicity , sugar , in vitro , chemistry , cancer cell , cell culture , potency , biochemistry , stereochemistry , cancer , biology , nucleotide , gene , genetics
A series of guanine 7‐nucleosides and their analogs modified in the sugar portion have been synthesized and evaluated for their cytotoxicity in vitro against five cancer cell lines (T98G, U‐251 MG, HeLa, SKOV‐3, T‐47D) with MRC‐5 (healthy cells) as a reference. Several guanine 7‐pentafuranosides and 7‐acyclo‐nucleosides have demonstrated a selective anti‐malignant potency at micromolar concentrations in the case of T98G and U‐251 MG glioma lines, while being totally inactive against other cancer cells.