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Concentrated Solar Radiation Aided Green Approach for Preparative Scale and Solvent‐Free Synthesis of 3‐Methyl‐4‐(hetero)arylmethylene Isoxazole‐5(4H)‐ones
Author(s) -
Gadkari Yatin U.,
Jadhav Nilesh L.,
Hatvate Navnath T.,
Telvekar Vikas N.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003348
Subject(s) - isoxazole , hydroxylamine hydrochloride , chemistry , hydroxylamine , ethyl acetoacetate , solvent , hydrochloride , catalysis , organic chemistry , combinatorial chemistry
An efficient, clean, and environmentally benign approach for the synthesis of 3‐methyl‐4‐arylmethylene isoxazole‐5(4H)‐ones has been developed using concentrated solar radiations (CSR). One pot, multicomponent synthesis from aromatic / heteroaromatic aldehydes, ethyl acetoacetate and hydroxylamine hydrochloride leads to title compounds in high yields. Notably the reaction has been carried out in under solvent and catalyst‐free conditions within a very short time (3 min). Further, the reaction was scaled up to 50 mmol. The present method is also energy efficient and saves almost more than 87 % of energy as compared to the conventional method.