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Desymmetrization of Cyclopentene‐1,3‐Diones via Alkylation, Arylation, Amidation and Cycloaddition Reactions
Author(s) -
Das Tapas
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003341
Subject(s) - desymmetrization , cyclopentene , stereocenter , cycloaddition , chemistry , alkylation , organic chemistry , combinatorial chemistry , organic synthesis , stereochemistry , enantioselective synthesis , catalysis
Desymmetrization of prochiral cyclopentene‐1,3‐diones for the synthesis of various natural products and moieties of pharmaceutically active compounds, is a very challenging and competitive area of research in organic synthesis now a days. It is a very powerful strategy to provide quaternary stereocenter having different functionality, which is very difficult to install by other C−C bond‐forming methods. This review describes an elaborative discussion of desymmetrization of cyclopentene‐1,3‐diones (racemic and asymmetric) via different alkylation, arylation, amidation and cycloaddition process for the last decades.