Palladium‐Catalyzed Cascade Carbonylative Cyclization Reaction of Trifluoroacetimidoyl Chlorides and 2‐Iodoanilines: Toward 2‐(Trifluoromethyl)quinazolin‐4(3H)‐ones Synthesis | Zendy

Yang Hefei | Zendy; Wang LeCheng | Zendy; Wang WeiFeng | Zendy; Chen Zhengkai | Zendy; Wu XiaoFeng | Zendy

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Palladium‐Catalyzed Cascade Carbonylative Cyclization Reaction of Trifluoroacetimidoyl Chlorides and 2‐Iodoanilines: Toward 2‐(Trifluoromethyl)quinazolin‐4(3H)‐ones Synthesis

Author(s) -

Yang Hefei,

Wang LeCheng,

Wang WeiFeng,

Chen Zhengkai,

Wu XiaoFeng

Publication year - 2020

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.202003269

Subject(s) - trifluoromethyl , chemistry , palladium , reagent , catalysis , cascade , combinatorial chemistry , organic chemistry , medicinal chemistry , chromatography , alkyl

A palladium‐catalyzed cascade carbonylative/cyclization reaction for the synthesis of 2‐(trifluoromethyl)quinazolin‐4(3 H )‐ones has been achieved. The transformation utilizes readily available 2‐iodoanilines and trifluoroacetimidoyl chlorides as the starting reagents, enabling a simple and convenient access to pharmaceutically significant quinazolin‐4(3 H )‐one derivatives.

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