Premium
Palladium‐Catalyzed Cascade Carbonylative Cyclization Reaction of Trifluoroacetimidoyl Chlorides and 2‐Iodoanilines: Toward 2‐(Trifluoromethyl)quinazolin‐4(3H)‐ones Synthesis
Author(s) -
Yang Hefei,
Wang LeCheng,
Wang WeiFeng,
Chen Zhengkai,
Wu XiaoFeng
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003269
Subject(s) - trifluoromethyl , chemistry , palladium , reagent , catalysis , cascade , combinatorial chemistry , organic chemistry , medicinal chemistry , chromatography , alkyl
A palladium‐catalyzed cascade carbonylative/cyclization reaction for the synthesis of 2‐(trifluoromethyl)quinazolin‐4(3 H )‐ones has been achieved. The transformation utilizes readily available 2‐iodoanilines and trifluoroacetimidoyl chlorides as the starting reagents, enabling a simple and convenient access to pharmaceutically significant quinazolin‐4(3 H )‐one derivatives.