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Synthesis and Application of ZIF‐8 MOF Incorporated in a TiO 2 @Chitosan Nanocomposite as a Strong Nanocarrier for the Drug Delivery of Acyclovir
Author(s) -
Akbari Mahdiyeh,
Ghasemzadeh Mohammad Ali,
Fadaeian Manoochehr
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003213
Subject(s) - nanocarriers , thermogravimetric analysis , chitosan , drug delivery , fourier transform infrared spectroscopy , nanocomposite , nuclear chemistry , materials science , chemical engineering , ultraviolet visible spectroscopy , spectroscopy , drug carrier , chemistry , nanotechnology , organic chemistry , engineering , physics , quantum mechanics
Recently, metal‐organic frameworks (MOFs) have been effectively established as potential nanocarriers for the drug delivery. In this study, we have examined a novel framework containing TiO 2 @Chitosan@ZIF‐8 for the delivery of acyclovir (ACV). The structure elucidation and physicochemical characterization of the prepared nanocarrier were investigated by various spectroscopic techniques such as Fourier‐transform infrared spectroscopy (FT‐IR), ultraviolet‐visible spectroscopy (UV‐Vis), energy‐dispersive X‐ray spectroscopy (EDX), X‐ray diffraction (XRD), field emission scanning electron microscopy (FE‐SEM), brunauer‐emmett‐teller (BET), and thermal gravimetric analysis (TGA). The obtained results demonstrated that 90 % of the acyclovir was loaded on the TiO 2 @Chitosan@ZIF‐8 framework. The drug release study was performed in PBS (phosphate buffer saline, pH:7.4) and AB (acetate buffer, pH:5) solutions, which showed 78 % and 82 % release within 3 days.