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Halogenation of Imidazo[1,2‐ α ]pyridines with DXDMH (X=Cl, Br and I) Using DMSO as a Solvent and an Oxidant
Author(s) -
Zhu Sha,
Wang Binbin,
Li Huiqin,
Xiao Wending,
Teng Fan,
Shen Haicheng,
Gui QingWen,
Li Zhouchao,
Jiang Hongmei
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003161
Subject(s) - halogenation , chemistry , solvent , dimethyl sulfoxide , sulfoxide , medicinal chemistry , oxidative phosphorylation , organic chemistry , combinatorial chemistry , biochemistry
A simple and inexpensive methodology is reported for the conversion of imidazo[1,2‐ α ]pyridines to 3‐halo imidazo[1,2‐ α ]pyridines via oxidative halogenation using DXDMH (X=Cl, Br and I) paired with dimethyl sulfoxide, which serves as the oxidants as well as cosolvent.