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Silver‐Catalyzed Trifluoromethylation of ortho CH Bonds in Anilines
Author(s) -
Nguyen Tung T.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003143
Subject(s) - trifluoromethylation , reagent , nitro , catalysis , chemistry , nucleophile , ketone , halogen , medicinal chemistry , organic chemistry , trifluoromethyl , alkyl
A method for ortho ‐trifluoromethylation of C−H bonds in anilines has been developed. Reactions used nucleophilic TMSCF 3 as trifluoromethylating reagent in the presence of silver pivalate (AgOPiv) catalyst. Functionalities such as halogen, nitro, and ketone groups were compatible with conditions.