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Improved In Vitro Antimycobacterial Activity of Trinuclear Complexes Cobalt(II,III) and Iron(III) with 2‐Furoic Acid against Mycolicibacterium smegmatis
Author(s) -
Lutsenko Irina A.,
Yambulatov Dmitriy S.,
Kiskin Mikhail A.,
Nelyubina Yulia V.,
Primakov Petr V.,
Bekker Olga B.,
Levitskiy Oleg A.,
Magdesieva Tatiana V.,
Imshennik Vladimir K.,
Maksimov Yurii V.,
Sidorov Aleksey A.,
Danilenko Valery N.,
Eremenko Igor L.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202003101
Subject(s) - cobalt , chemistry , isostructural , carboxylate , mössbauer spectroscopy , moiety , stereochemistry , metal , medicinal chemistry , crystallography , inorganic chemistry , crystal structure , organic chemistry
The reaction of cobalt(II) and iron(III) pivalates with anions of 2‐furancarboxylic acid (pyromucic acid, Hfur) yielded trinuclear homometallic complexes with linear ([Co 3 (fur) 6 (phen) 2 ] ( 1 , phen=1,10‐phenanthroline)) and triangular ([Co 3 O(fur) 6 (H 2 O) 3 ] ( 3 ), [Fe 3 O(fur) 6 (THF) 3 ] ⋅ 3THF ( 4 )) structures of the metal moiety. The hexanuclear mixed carboxylate cobalt complex [Co 6 (piv) 8 (Hpiv) 4 (fur) 2 (OH) 2 ] ( 2 , piv − =(CH 3 ) 3 COO − ) was isolated as an intermediate in the synthesis of 3 . According to CVA data, complex 3 contains bivalent and trivalent cobalt ions. According to Mossbauer spectroscopy data, all the iron(III) atoms in 4 , which is an isostructural analogue of 3 , are solely in the high‐spin state. The antibacterial activity of compounds 1 – 4 , K(fur) ( 5 ) and Na(fur) ( 6 ) was determined in vitro against a non‐pathogenic Mycolicibacterium smegmatis strain. The results of in vitro biological tests against Mycolicibacterium smegmatis showed a high bioactivity of complexes 1 and 4 .