Premium
Copper‐Catalyzed [2+2+1+1] Annulation for the Regioselective Synthesis of 2,6‐Diarylpyridines via C1‐Insertion and Subsequent Cyclization
Author(s) -
Vodnala Nagaraju,
Gujjarappa Raghuram,
Satheesh Vanaparthi,
Gupta Richa,
Kaldhi Dhananjaya,
Kabi Arup K.,
Malakar Chandi C.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002968
Subject(s) - annulation , regioselectivity , synthon , chemistry , catalysis , combinatorial chemistry , organic chemistry , medicinal chemistry
Copper‐catalyzed [2+2+1+1] annulation strategy has been investigated for the regioselective synthesis of symmetrical and unsymmetrical 2,6‐diarylpyridines using aliphatic amines as nitrogen source and DMSO as C1‐synthon. The developed protocol was successful for the transformation of non‐activated aromatic ketones and non‐activated aliphatic amines into 2,6‐diarylpyridines via an “easy to access” approach. This protocol has been verified on wide range of substrates having various functional groups.