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DBU: A Reaction Product Component
Author(s) -
Muzart Jacques
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002910
Subject(s) - chemistry , nucleophile , amidine , component (thermodynamics) , steric effects , organic chemistry , nucleophilic addition , base (topology) , product (mathematics) , combinatorial chemistry , catalysis , physics , geometry , mathematics , thermodynamics , mathematical analysis
DBU (1,8‐diazabicyclo[5.4.0]undec‐7‐ene) is traditionally considered to be a non‐nucleophilic base. Nevertheless, DBU possesses nucleophilic properties which mediate organic reactions and may lead to the formation of compounds containing the DBU scaffold. Participation of water to the processes affords there‐component products. The review covers the reactions leading to DBU derivatives showing that the interest of this sterically hindered amidine is not limited to its basic role. Proposed mechanisms are described with, in some cases, personal comments.