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Ruthenium‐Based Structural Mimics of the Cofactor of [Fe]‐Hydrogenase: Replacement of the Acyl Moiety with an N‐Heterocyclic Carbene
Author(s) -
Barik Chandan Kr,
Chan Xian Qi,
Huynh Han Vinh,
Li Yongxin,
Ganguly Rakesh,
Leong Weng Kee
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002889
Subject(s) - moiety , ruthenium , carbene , chemistry , cofactor , ligand (biochemistry) , combinatorial chemistry , stereochemistry , hydrogenase , catalysis , organic chemistry , enzyme , biochemistry , receptor
A synthetic route is reported towards ruthenium‐based structural mimics of the [Fe]‐hydrogenase metal cofactor in which the acyl moiety is replaced by an N‐heterocyclic carbene. It is observed that the pyridyl‐NHC ligand has a rather different trans influence from that of a simple NHC in their ruthenium derivatives. The basis for this difference is explored crystallographically and computationally, and it accounts for their different behaviour towards thiolation.