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An Efficient and Facile Synthesis of Deuterium‐Labeled D‐Glycerolphosphocholine and 2,3‐Dilinoleoyl‐sn‐glycero‐3‐phosphocholine
Author(s) -
Gao Yong,
Zhang Yinsheng
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002799
Subject(s) - phosphocholine , deuterium , chemistry , analyte , combinatorial chemistry , radiochemistry , chromatography , phospholipid , physics , biochemistry , nuclear physics , membrane , phosphatidylcholine
Stable isotope‐labeled polyene phosphatidylcholines (PCs) were required for quantitative bioanalytical assays of products extracted from soybeans. A facile and efficient method for the synthesis of both [D 9 ] and [D 13 ]2,3‐dilinoleoyl‐sn‐glycero‐3‐phosphocholine ([D 9 ] & [D 13 ]DLPC) in excellent yields and high isotope‐enrichment has been developed applying cheap and commercially available glycine, 2‐aminoethanol and iodomethane‐ d 3 (99 %, 2 H) as starting materials and deuterium sources. [D 9 ]DLPC and [D 13 ]DLPC can be used as an internal standard and/or as a surrogate analyte.