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Investigating the Immunostimulatory and Immunomodulatory Effects of cis and trans Isomers of Ruthenium Polypyridyl Complexes on the Mammalian Macrophage‐Like Cells
Author(s) -
Ayaz Furkan,
Colak Suleyman Gokhan,
Ocakoglu Kasim
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002784
Subject(s) - immune system , tumor necrosis factor alpha , macrophage , ruthenium , adjuvant , cytokine , interferon , chemistry , autoimmunity , microbiology and biotechnology , in vitro , biology , cancer research , immunology , biochemistry , catalysis
Immunomodulatory and immunostimulatory compounds are drug candidates for the regulation of the function of immune system cells to fight against disease conditions including cancer to autoimmunity as well as inflammatory disorders. Due to the electron transfer capacity of photosensitizers in solar cell structures, we hypothesized that they can also be used to regulate the immune system cells’ functions possibly through interfering with their electron transfer related activities. We examined the cis and trans isomers ( cis ‐Ru and trans ‐Ru) of ruthenium polypyridyl complex on the activated macrophage‐like cells in vitro . Our results suggest immunostimulatory and positive immunomodulatory roles for the ruthenium complex.These compounds increased the production of tumor necrosis factor (TNF) pro‐inflammatory cytokine by macrophage‐like cells. Therefore, both cis and trans isomers can be used as a new generation of adjuvant candidates in the vaccine formulations to further boost the activity of immune cells against the disease agent or antigen.