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Synthesis of Macrocyclic β‐Peptidomimetics by Ring‐Closing Metathesis
Author(s) -
Hieu Tran Dinh,
Tu Nguyen Xuan,
Minh Chau Tran Thi,
Quynh Le Thuy,
Ho Oh Chang,
Hung Mac Dinh
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002706
Subject(s) - peptidomimetic , alkene , ring closing metathesis , ring (chemistry) , metathesis , closing (real estate) , stereochemistry , chemistry , catalysis , salt metathesis reaction , combinatorial chemistry , organic chemistry , peptide , biochemistry , polymer , political science , law , polymerization
The synthesis of a series of conformationally constrained peptidomimetics containing a 9‐to‐13‐atom‐membered ring by ring‐closing metathesis (RCM) is described. The second‐generation Grubbs catalyst proved to be the most effective in producing the desired cyclic β‐peptidomimetics with moderate to good yields. Reaction characteristics such as the influence of alkene chain length in the precursors, position of double bond and ring size of products were also discussed.