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Facile Synthesis and Biological Evaluation of New Thieno[2,3‐g]indolizine Derivatives
Author(s) -
Zinoveva Anna D.,
Borisova Tatia.,
Politova Polina A.,
Titov Alexander A.,
Varlamov Alexey V.,
Voskressensky Leonid G.,
Nguyen Van Tuyen,
Le Tuan Anh
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002684
Subject(s) - indolizine , reagent , chemistry , domino , maleic anhydride , tricyclic , organic chemistry , acrylic acid , combinatorial chemistry , monomer , catalysis , copolymer , polymer
An effective approach to the synthesis of thieno[2,3‐ g ]indolizine derivatives has been developed. A wide variety of reagents such as unsaturated aldehydes, methylvinylketone, esters of acrylic acid, maleic anhydride, methyl propiolate, dimethyl and diethyl acetylenedicarboxylates in the construction of functionally diverse rarely encountered tricyclic system has been used. A high number of structurally various thieno[2,3‐g]indolizines has been obtained in domino reactions with medium and high yields, the influence of solvents on the course of transformations has been studied, and the presence of moderate cytotoxic activity for a number of compounds has been established.