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Kaurenoic Acid Induces Cell Cycle Arrest and Apoptosis in the MCF‐7 Breast Cancer Cell Line
Author(s) -
Roberto de Souza Anderson,
Stefany de Souza Castro Mona,
Olímpio de Souza Thiago,
Cassio Sola Veneziani Rodrigo,
Kenupp Bastos Jairo,
Ricardo Ambrósio Sérgio,
Alves dos Santos Raquel
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002638
Subject(s) - mcf 7 , apoptosis , cytotoxic t cell , cell cycle checkpoint , cell cycle , cancer research , cancer , breast cancer , programmed cell death , cell culture , biology , cancer cell , dna damage , cell , chemistry , medicine , in vitro , dna , biochemistry , genetics , human breast
Breast cancer continues to be the major cause of cancer death among women. The high genetic heterogeneity and chemoresistant phenotypes of breast tumors require the search for new compounds to expand the options for the treatment of this disease. Kaurenoic acid (KA) is an ent ‐kaurane type‐diterpene with cytotoxic and genotoxic effects against gastric and cervical cancer cells. In the present study, we report the antiproliferative effects of KA in the breast tumoral cell line MCF‐7 and the normal breast counterpart MCF‐10 A. The long‐term cytotoxic effects of KA were observed by the reduction of survival fraction at 50 and 100 μM. At these concentrations, the treatment with KA increased the extension of DNA damage followed by G1 cell cycle phase accumulation and induction of apoptosis in both cell lines. Taken together, the results contained herein support the promising antiproliferative effects of KA.