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Annulation of Ketene Dithioacetals and Sulfonyl Hydrazines for the Synthesis of N ‐Sulfonyl 5‐Alkylthiopyrazoles
Author(s) -
Li Yi,
Wan JiePing,
Liu Yunyun
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002480
Subject(s) - sulfonyl , ketene , chemistry , annulation , organic chemistry , catalysis , alkyl
A facile method for the synthesis of pyrazoles bearing novel N ‐sulfonyl and 5‐alkylthio functional substructures has been developed via the reactions of ketene dithioacetals and sulfonyl hydrazines. The reactions are conducted with simple p ‐toluenesulfonic acid ( p ‐TSA) promotion and mild heating under air atmosphere, leading to the synthesis of target products with highly diverse functional substitution.