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Synthesis, Photooxygenation and DNA Studies of Novel Fused Furo, Dioxolo, and Dioxino Derivatives of Coumarin
Author(s) -
Elgogary Sameh Ramadan
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002442
Subject(s) - furocoumarin , photooxygenation , coumarin , chemistry , chloroacetyl chloride , furocoumarins , derivative (finance) , psoralen , combinatorial chemistry , dna , organic chemistry , chloride , photochemistry , biochemistry , singlet oxygen , oxygen , financial economics , economics
Syntheses of novel fused furo, dioxolo and dioxino derivatives of coumarin are carried out through the reaction of 7,8‐dihydroxycoumarin derivative 1 with α‐halocarbonyl compounds (α‐haloketone, α‐haloester and chloroacetyl chloride) and 1,2‐dichloroethane. The photooxygenation of synthesized furocoumarin derivative was performed and the affinity of furocoumarin derivative towards DNA was evaluated and compared with 8‐methoxypsoralen (8‐MOP), which extensively used in photochemotherapy.