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Allylic Selenocyanates as Antifungal Agents Against Pathogenic Candida Species
Author(s) -
Bazana Luana C. G.,
Carvalho Ânderson R.,
Silveira Gustavo P.,
S. de Oliveira Luis Flávio,
Teixeira Mário L.,
Lopes William,
Vainstein Marilene H.,
Barbosa Flavio A. R.,
Russo Theo V. C.,
Sá Marcus M.,
Canto Rômulo F. S.,
Fuentefria Alexandre M.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002170
Subject(s) - antifungal , cytotoxicity , microbiology and biotechnology , ergosterol , minimum inhibitory concentration , candida infections , biology , chemistry , antimicrobial , in vitro , biochemistry
Candida is a genus that causes the highest number of fungal infections on people around the world, responsible for high mortality rates in critical and immunocompromised patients. Even though several antifungals are commercially available, most of these have side effects or are only available for intravenous administration. In view of this aspect, the susceptibility of twelve allylic selenocyanate (AS) compounds, five of them novel, were tested against 36 Candida strains. The AS were active for all Candida strains reaching minimal inhibitory concentrations (MIC) in the order of ng mL −1 (0.39–50 μg mL −1 ). The sorbitol and ergosterol assay show that these compounds do not act on the cell wall and fungal membrane, suggesting a different mechanism of action. Cytotoxicity and irritability tests showed that only three molecules already studied ( 2 b , 2 j and 2 i ) for this series manifested damage to the leukocyte cell and chorioallantoic membrane, but at higher concentrations than the MICs. Considering the susceptibility results and parameters of Lipinski, molecules 2 c (0.39–12.5 μg mL −1 ) and 2 d (0.78–6.2 μg mL −1 ) look promising for the development of a new antifungal agent against Candida infections.