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Synthesis of New and Highly Functionalized 1,4‐Dihydropyridines and Spirooxindole Dihydropyridines Using L‐Proline as Efficient Catalyst
Author(s) -
Neamani Shekofeh,
Moradi Leila
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202002146
Subject(s) - malononitrile , catalysis , chemistry , dihydropyridine , reaction conditions , one pot synthesis , homogeneous , solvent , proline , combinatorial chemistry , organic chemistry , mathematics , calcium , amino acid , biochemistry , combinatorics
Herein, eco‐friendly, mild and efficient synthesis of a new type of 1,4‐ dihydropyridines and some of the spirooxoindole dihydropyridine derivatives was developed by using L‐proline as an effective homogeneous catalyst. The one‐pot multicomponent reaction of malononitrile, different anilines, and benzaldehydes were performed in the presence of Water/EtOH (1 : 1) as solvent at 90 °C and furnished the corresponding products in high yields. Further, we developed a three‐component one‐pot reaction of malononitrile, anilolactone, and differently substituted isatins to afford new spirooxindole dihydropyridine derivatives using the same catalyst and conditions. All of the obtained products were characterized by spectroscopic and analytical techniques.