Synthesis of New 3‐(2‐Amino‐6‐arylpyrimidin‐4‐yl)‐4‐hydroxyquinolin‐2(1 H )‐ones and Their In Vitro Antimicrobial and “DPPH” Scavenging Activity Evaluation | Zendy

Krishna Alla. | Zendy; Vijayakumar V. | Zendy; Sarveswari S. | Zendy

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Synthesis of New 3‐(2‐Amino‐6‐arylpyrimidin‐4‐yl)‐4‐hydroxyquinolin‐2(1 H )‐ones and Their In Vitro Antimicrobial and “DPPH” Scavenging Activity Evaluation

Author(s) -

Krishna Alla.,

Vijayakumar V.,

Sarveswari S.

Publication year - 2020

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.202002082

Subject(s) - antimicrobial , dpph , candida albicans , bacillus cereus , chemistry , candida parapsilosis , ascorbic acid , staphylococcus aureus , candida glabrata , aspergillus niger , microbiology and biotechnology , antioxidant , biology , organic chemistry , biochemistry , bacteria , food science , genetics

An efficient multi component reaction for the synthesis of new 3‐(2‐amino‐6‐arylpyrimidin‐4‐yl)‐4‐hydroxyquinolin‐2(1 H )‐ones has been described. Synthesized derivatives were screened for their in vitro antimicrobial and 2, 2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging activity. Among the tested compounds 3 k , 3 m and 3 r shown better antibacterial properties and have displayed broad spectrum of activity than Neomycin against Staphylococcus aureus , Bacillus cereus, Klebsiella planticola , Escherechia coli, S.aureus and Pseudomonas aeruginosa . Moreover 3 r , 3 t and 3 n were found to have potent antifungal activity against Candida parapsilosis, Candida albicans , Aspergillus niger , Candida glabrata , Issatchenkia hanoiensis and Candida than the standard Miconazole. Furthermore 3 c , 3 j , 3 d , 3 m , and 3 h showed strong DPPH free radical scavenging activity than Ascorbic acid.

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