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Antioxidant, Antibacterial and Anticancer Performance of Reduced Graphene Oxide Prepared via Green Tea Extract Assisted Biosynthesis
Author(s) -
Vatandost Elham,
Saraei Azade GhorbaniHasan,
Chekin Fereshteh,
Raeisi Shahram Naghizadeh,
Shahidi SeyedAhmad
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001920
Subject(s) - green tea extract , dpph , chemistry , polyphenol , antioxidant , cytotoxicity , antibacterial activity , nuclear chemistry , combinatorial chemistry , biochemistry , food science , green tea , biology , bacteria , in vitro , genetics
Abstract Green tea extract (GTE) contains polyphenols and can play as a bioreducing and stabilizing agent. This paper describes environmentally friendly approach for synthesis of reduced graphene oxide using GTE (GTE‐rGO). The results have confirmed that biomolecules present in green tea extract not only act as bioreductant but also functionalize the surface of rGO due to hydrogen binding and π‐π stacking interactions. The 100 ppm of rGTE‐rGO showed 0.68 ppm phenols and 0.24 ppm flavones. The rGTE‐rGO was found to have highest % of 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH, 73.83 %) scavenging activity. Antibacterial activity of GTE‐rGO exhibited strong activity against Escherichia coli and Staphylococus. A cytotoxicity evaluation of GO and GTE‐rGO was carried out on fibroblast, MCF7 breast cancer and PC3 prostat cancer cells. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) results showed high viability loss and toxicity of GTE‐rGO against cells especially for PC3 cells. Thus, GTE‐rGO because of biomolecules present could potentially act as antioxidant, anticancer and antibacterial agent.