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Simple and Efficient Synthesis of Guanidine‐Based Magnetic Nanocatalyst for the One‐Pot, Four‐Component Synthesis of Polyhydroquinolines in Water
Author(s) -
Aghahosseini Hamideh,
Ranjbar Mohammad Reza,
Ramazani Ali
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001903
Subject(s) - guanidine , cyanuric chloride , catalysis , magnetic nanoparticles , component (thermodynamics) , combinatorial chemistry , chemistry , covalent bond , one pot synthesis , nanoparticle , organic chemistry , materials science , nanotechnology , physics , thermodynamics
A new guanidine‐based magnetic nanocatalyst was prepared according to a three‐step operationally simple process using simple, cheap and readily‐available chemicals. Guanidine as the organocatalytic center was covalently attached to amino‐functionalized magnetic nanoparticles via cyanuric chloride as a cross‐linking agent. The developed nanocatalyst was employed efficiently for the one‐pot, four‐component synthesis of polyhydroquinolines as the medicinally important polycyclic heterocycle compounds in water according to a convenient catalytic procedure. The nanocatalyst could be magnetically separated from the reaction mixture and reused for several times. The reaction profile was very clean and only 0.2 mol% of catalyst is needed to obtain products in excellent yields at very short reaction times according to an easy work‐up procedure.