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Chiral Oxazolinyl Hydroxyl Ferrocene Catalysts: Synthesis and Applications in Asymmetric Reactions
Author(s) -
Xu Di,
Zhang Jun,
Dai Li
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001874
Subject(s) - enantioselective synthesis , chemistry , catalysis , ferrocene , combinatorial chemistry , chirality (physics) , nucleophile , planar chirality , reagent , nucleophilic substitution , organic chemistry , chiral symmetry breaking , physics , electrode , quantum mechanics , nambu–jona lasinio model , electrochemistry , quark
Chiral oxazolinyl hydroxyl ferrocenes have been demonstrated as representative catalysts in enantioselective nucleophilic addition reactions in the last few decades. They have received much interest from chemists because of not only the numerous substitution patterns at their sandwich backbones, but also their superior catalytic activity in asymmetric transformations. Recent research has revealed that the planar chirality of these catalysts influences the stereochemistry of asymmetric products and the application scope in enantioselective reactions. Herein, we provide an intensive survey of chiral oxazolinyl hydroxyl ferrocene compounds, including the structures of chiral compounds already published, designed synthetic approaches for ferrocenes with different patterns, and their utilization in the enantioselective preparation of secondary alcohols using organozinc reagents.