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HClO 4 ‐Al 2 O 3 as a Prominent Catalyst in the Synthesis of 3,4‐Dihydropyrimidin‐2(1 H )‐ones/thiones under Environmentally Friendly Solvent Conditions
Author(s) -
Zanin Lucas L.,
Porto André L. M.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001830
Subject(s) - catalysis , yield (engineering) , reagent , chemistry , heterogeneous catalysis , organic chemistry , nuclear chemistry , materials science , metallurgy
An accessible, non‐toxic, easy to handle and stock catalyst with high efficiency was developed in this study for the synthesis of 3,4‐dihydropyrimidin‐2(1 H )‐ones/thiones. Al 2 O 3 was used as a support for HClO 4 , resulting in a heterogeneous and reusable catalyst for the Biginelli reaction. In the absence of the catalyst, the reaction provided a yield of 19%. However, in the presence of HClO 4 ‐Al 2 O 3 it was possible to synthesize 16 examples of DHPMs/thiones with improved yields (80‐98%), in reaction periods of 1 to 3 hours. The catalyst also stood out for its stability against temperature and the reagents used.