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Free Radical Triggered Convenient Synthesis of Bis(indolyl)methane with Potassium Peroxodisulfate as Catalyst
Author(s) -
Konwar Dipika,
Bora Utpal
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001776
Subject(s) - yield (engineering) , chemistry , catalysis , methane , aldehyde , indole test , potassium , steric effects , substrate (aquarium) , radical , nitro , organic chemistry , combinatorial chemistry , medicinal chemistry , materials science , oceanography , alkyl , metallurgy , geology
The free radical triggered convenient synthesis of bis(indolyl)methane using various indole and aldehyde derivatives with potassium peroxodisulfate as catalyst under the ambient conditions is developed. This protocol exhibits a wide range of sterically and electronically diverse substrate scope with good to excellent yield (up to 94 %) of the desired product without aecting the bromo, chloro, iodo, nitro, methoxy, and hydroxyl groups. The experimental observation indicates that the reaction follow a radical pathway.
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