Premium
[3+3] Cycloaddition of Azomethine Imine: Synthesis of Bi‐ or Tricyclic N‐Heterocycle
Author(s) -
Das Tapas,
Sau Madan,
Daripa Bishnu,
Karmakar Dipanjan,
Chakraborty Sayan
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001674
Subject(s) - cycloaddition , imine , chemistry , tricyclic , catalysis , lewis acids and bases , combinatorial chemistry , organic chemistry
Synthesis of six‐membered bicyclic, tricyclic or tetracyclic N‐heterocycles are important due to enormous use of such scaffolds in bioactive natural products, agrochemicals and in pharmaceuticals. [3+3] cycloaddition of azomethine imine for the construction of such heterocycles is less explored but also a genuine approach with the other method like [4+2] and [2+2+2] cycloaddition. Hence, the literature survey in this area is utmost significant. The delights and difficulties of [3+3] cycloaddition of azomethine imine have been deliberated thoroughly to elucidate this highly mounting field in this literature study. Herein, we report a vast synthetic method [base catalyzed, metal catalyzed (racemic and asymmetric), phosphine catalyzed, NHC and Lewis acid catalyzed] for the synthesis of di, tri and tetra‐nitrogen containing heterocycles via [3+3] cycloadditon reaction of azomethine imine.