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Application of N ‐Aryl Ethanolamines as N,O ‐Ligand in Nickel(II)‐Catalyzed Carbon‐Carbon Bond Formation in Heck Coupling Reactions
Author(s) -
Bhange Dattatraya S.,
Sonawane Rahul B.,
Rasal Nishant K.,
Jagtap Sangeeta V.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001578
Subject(s) - aryl , chemistry , catalysis , coupling reaction , halide , heck reaction , nickel , ligand (biochemistry) , ethanolamines , medicinal chemistry , polymer chemistry , organic chemistry , ethanolamine , alkyl , biochemistry , receptor
A simple and efficient protocol of Ni‐(II) catalyzed C−C bond formation in Heck coupling reactions of a variety of alkenes and aryl and hetero aryl halides, using various N ‐aryl ethanolamines as bi‐dentate N,O ‐ligand with moderate to excellent yields is described here. The application of different N ‐aryl ethanolamines in presence of NiCl 2 .6H 2 O catalyst is tested for C−C bond formation in Heck reactions and found to be efficient in homogeneous medium. This simple and efficient protocol shows a broad substrate scope for substituted alkenes, aryl and hetero aryl halides and tolerates various functional groups and successfully demonstrated by 31 examples.