Tunable Synthesis of Mesoporous Prussian Blue@Calcium Phosphate Nanoparticles for Synergic Chemo‐Photothermal Cancer Therapy | Zendy

Yu Baohui | Zendy; Wang Chungang | Zendy

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Tunable Synthesis of Mesoporous Prussian Blue@Calcium Phosphate Nanoparticles for Synergic Chemo‐Photothermal Cancer Therapy

Author(s) -

Yu Baohui,

Wang Chungang

Publication year - 2020

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.202001234

Subject(s) - prussian blue , photothermal therapy , mesoporous material , nanoparticle , drug delivery , materials science , chemistry , photothermal effect , nanotechnology , nuclear chemistry , chemical engineering , organic chemistry , catalysis , electrode , electrochemistry , engineering

A facile and mild strategy to prepare the mesoporous prussian blue@calcium phosphate core‐shell nanoparticles (M‐PB@CaP core‐shell NPs) composed with a MCaP shell and a MPB core is reported. The obtained NPs exhibited strong absorption in the near infrared (NIR) region and possessed an excellent photothermal efficiency of 26 % resulting from the PB core. The mesoporous structure of PB, CaP and the appearance of PAA in the M‐PB@CaP core‐shell NPs are greatly favorable for the ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs) of the NPs. When the DOX‐loaded M‐PB@CaP core‐shell NPs were exposed to NIR irradiation, a burst‐like drug release occurs on account of the heat produced by the M‐PB@CaP core‐shell NPs. These results indicate that the obtained NPs could employ as pH/NIR dual‐responsive drug delivery systems for synergistic chemo‐photothermal therapy of cancer cells.

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