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Shape‐Controlled Synthesis of Multicomponent‐Encapsulating Alginate Microparticles: Peanut‐, Spherical‐, and Disc‐Shaped Transformations
Author(s) -
Bai MengYi,
Wang TingTeng,
Chen ShiuHsin,
Wang YuChi,
Yu MuHsien
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001174
Subject(s) - microparticle , materials science , microsphere , drug delivery , calcium alginate , spray drying , chemical engineering , particle size , biomedical engineering , composite material , chemistry , nanotechnology , calcium , chromatography , metallurgy , medicine , engineering
Multicomponent‐encapsulating alginate microparticles were prepared using an electrospray system. The resultant particles were subject to stirring (varied from 0–1000 rpm) and cross‐linking processes with various concentrations of calcium chloride (varied from 2–16 wt %). We determined that a balance should be maintained between the stirring rate (related to the shear force) and cross‐linking degree (related to the hardness of the particle) to reach the shape control. The shape of the particle can be varied from a peanut shape to a disc shape, with up to 95.43 %±1.84 % monodispersed shape distribution. A microparticle drug encapsulation efficiency of 98 % was achieved, and the cell toxicity effect of reduction of 20–40 % growth toward ovarian cancer cell lines SKOV‐3 and CP70 by using the disk‐shape microparticle‐treated group was achieved, which is similar to that of 1/3 freeform dosage treatment group. Hyperthermia can be incorporated and integrated with chemotherapeutic treatment by applying an alternating magnetic field to multicomponent‐encapsulated alginate microparticles to further enhance the efficacy of treatment. The results of this study indicate that alginate particles can be used as drug carriers for ovarian cancer treatment and potentially for treatment of intraperitoneal metastatic carcinoma via spraying these disk‐shaped microparticles for internal lining attachment.