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Design and Synthesis of Aminoacetylenic Indole and Carbazole Hybrid Compounds
Author(s) -
AlQawasmeh Raed A.,
Hussein Nura A.,
Shehadi Ihsan,
Khanfar Monther A.,
Salameh Bader A.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001146
Subject(s) - carbazole , indole test , chemistry , formaldehyde , catalysis , mannich reaction , mass spectrum , coupling reaction , carbon 13 nmr , combinatorial chemistry , organic chemistry , polymer chemistry , ion
A novel series of aminoacetylenic indole and carbazole hybrid compounds had been prepared via a three‐component reaction system in which a mannich type reaction was used in the coupling of propargylic indole or carbazole with cyclic amines and formaldehyde in the presence of Cu(I) catalyst. A side product of the self‐coupling reaction of propargylic indole was also separated and characterized by physicochemical techniques. NMR, single crystal x‐ray, High‐resolution mass spectra (HRMS) are used in the characterization of the synthesized compounds and intermediates