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Noscapine‐Loaded Nanostructured Lipid Carriers as a Potential Topical Delivery to Bovine Mastitis Treatment
Author(s) -
Otarola Jessica J.,
Alejandra Luna Maria,
Mariano Correa Néstor,
Molina Patricia G.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202001138
Subject(s) - zeta potential , solid lipid nanoparticle , chemistry , drug delivery , dynamic light scattering , carbon paste electrode , nanoparticle , materials science , chromatography , nanotechnology , cyclic voltammetry , electrode , organic chemistry , electrochemistry
Noscapine (NO) is a lipophilic benzylisoquinoline alkaloid with antioxidant, antitussive and anti‐cancer properties. This study aimed to incorporate this alkaloid into an innovative topical gel‐based on nanostructured lipid carrier (NLCs) to facilitate its incorporation and distribution into the organism to bovine mastitis treatment. Drug release studies were carried out using square wave voltammetry (SWV) as an alternative technique. The NLCs showed a 100 % encapsulation efficiency and, a fast release profile, releasing 86.7 % of the incorporated NO in 5 hours. On the other hand, the lipid nanoparticles′ stability was analyzed using SWV and transmission electron microscope techniques. For these studies, NLCs with and without NO incorporated were immobilized onto a carbon paste electrode and exposed to free radicals attack. The stability studies were assisted with dynamic light scattering. The results reveal a promising alternative drug delivery system for NO topical application.